Cisplatin mitophagy
WebNov 26, 2024 · Cisplatin is one of the commonly used anticancer drugs in clinic chemotherapy, but drug resistance is a major therapeutic obstacle for successful treatment. While ginkgolic C17:1 alone induced autophagy and apoptosis in the human hepatoblastoma cells HepG2, it was found to paradoxically inhibit cisplatin-induced … WebCisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and apoptosis, in the other hand semaglutide treatment has …
Cisplatin mitophagy
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WebJul 5, 2024 · Mitophagy is a cytoprotective process in the adaptation to chemotherapy drug treatment. Therefore, targeting mitochondria is regarded as a promising anticancer … WebNov 11, 2024 · Mitophagy reportedly can prevent diabetic nephropathy, cisplatin-induced AKI and other related nephropathy. In this study, we evaluated the correlation between mitophagy and the protective effect of the Nrf2 activator farrerol on cisplatin-induced CKD by using C57BL/6 wild-type and Nrf2 knockout mice.
WebDec 1, 2024 · The “oncoPredict” package showed that the high risk mitophagy group had a lower sensitive score than low risk mitophagy group in a series of drugs (Table 1). To be noted, compared to low risk mitophagy group, the high risk mitophagy was more sensitive to cisplatin and gemcitabine, which were often used in the treatment of LUAD. 3.5. WebJun 1, 2024 · Modulation of cisplatin-induced apoptosis by stimulation or suppression of mitophagy. (A) Cisplatin stimulates apoptosis in HCT116 and SK-N-BE(2) assessed by …
WebScience topic Sirtuin 1. A sirtuin family member found primarily in the CELL NUCLEUS. It is an NAD-dependent deacetylase with specificity towards HISTONES and a variety of proteins involved in ... WebApr 22, 2024 · Specifically, levels of the mitophagy receptor BNIP3 are higher both in resistant cells and in ovarian cancer patient samples resistant to platinum-based treatments. Genetic BNIP3 silencing or pharmacological inhibition of autophagosome formation re-sensitizes these cells to CDDP.
WebNov 1, 2024 · Abstract. Cisplatin is a widely used chemotherapeutic drug with notorious toxicity in the kidneys, which involves mitochondrial dysfunction and damage in renal …
WebOct 12, 2024 · Gastric cancer (GC) is one of the most common tumors worldwide, and cisplatin is a standard chemotherapeutic reagent for GC treatment. However, chemoresistance is an inherent challenge which limits its application and effectiveness in clinic. This study aims to investigate the mechanism of metformin-induced cisplatin … state of wisconsin meal reimbursementWebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of … state of wisconsin mbeWebOct 7, 2024 · Chaetomugilin J Inhibits Mitophagy Induced by Cisplatin. Mitophagy is a type of autophagy that eliminates redundant or damaged mitochondria. 26 It plays an important role in mitochondrial function. The expression of pink1 and parkin, which are mitophagy-related proteins, were detected to reflect mitophagy. state of wisconsin map with cities and townsWebCisplatin is widely recommended in combination for the treatment of tumors, thus inevitably increasing the incidence of cisplatin-induced acute kidney injury. Mitophagy is a type of … state of wisconsin mirsWebCisplatin exerts its therapeutic efficacy by interfering with DNA replication but also by interacting with other nucleophilic species within cells, including side chains of … state of wisconsin new hire formWebSep 25, 2024 · Meanwhile, mitophagy indicated by autophagosome formation and LC3B-II accumulation was also attenuated in PINK1 knockout rats. Renal expression of PINK1 and Parkin were down-regulated while BNIP3L was up-regulated by cisplatin treatment, indicating a major role of BNIP3/BNIP3L pathway in cisplatin-induced mitophagy. state of wisconsin milwaukeeWebMar 15, 2024 · It has been found that PNS is able to alleviate cisplatin-induced nephrotoxicity by inducing BNIP3-mediated mitophagy via hypoxia-inducible factor-1α (HIF-1α). PNS treatment restores renal function via attenuating the accumulation of injury mitochondria and cell apoptosis in TECs ( Liang et al., 2024 ; Li et al., 2024c ). state of wisconsin minimum wage 2021