site stats

Cytoplasmic sox10

WebJan 1, 2014 · (B) Sox10 immunohistochemistry results in diffuse crisp nuclear staining in all granular tumor cells in cutaneous GCTs, 400×. (C) Noncutaneous GCTs from breast (top) and tongue (bottom), as well as other deep tissue sites, also showed diffuse nuclear staining in all granular tumor cells. WebAbstract. SOX10 (Sry-related HMg-Box gene 10) is a key nuclear transcription factor in the differentiation of neural crest progenitor cells to melanocytes. It has been …

Structural basis for nuclear import selectivity of pioneer

WebJun 20, 2014 · Cytoplasmic staining for the pan-melanoma cocktail and nuclear staining for SOX10 and MITF were scored by 2 pathologists (J.C. and Y.G.). Positive staining in >1% … WebMar 7, 2016 · Sox10 is a transcription factor of the sex determining region Y (SRY)-related high motility group (HMG)-box gene family. It plays an important role in the maintenance and migration of neural crest stem cells [ 1 – 4 ], and in their differentiation into neural crest-derived melanocytes and glia [ 5, 6 ]. target batch app download for pc https://teachfoundation.net

Cutaneous soft tissue tumors: diagnostically disorienting …

WebNordic Immunohistochemical Quality Control, SOX10 run 60 2024 Page 1 of 9 Assessment Run 60 2024 Transcription factor SOX-10 (SOX10) Purpose Evaluation of the technical performance, level of analytical sensitivity and specificity of IHC tests among ... a weak cytoplasmic staining reaction of ganglion/neuronic cells in the appendix was accepted ... WebFeb 6, 2024 · The relocalization of ectopic Neurog2 from the nucleus to the cytoplasm suggests the possibility that overexpression of Sox10 promotes ubiquitination of Neurog2, which could occur in both compartments as evidenced by another short-lived bHLH transcription factor, MyoD ( 26 ). WebJul 6, 2024 · In postnatal mice, melanocytes maintain and are maintained by expression of high levels of Sox10, while Sox10 activity in melanocyte stem cells is decreased 38. It is commonly accepted that ... target basmati organic white rice from india

SOX10 - Wikipedia

Category:Sox10 Is an Active Nucleocytoplasmic Shuttle Protein, and …

Tags:Cytoplasmic sox10

Cytoplasmic sox10

Sox10 is expressed in primary melanocytic neoplasms of various ...

WebSOX10 and/or S100 protein immunopositivity in conjunction with rearrangement of the PLAG1 gene assisted in reclassification of a subset of oncocytomas as oncocytic variants of PA and ME. Therefore, we recommend to include S100 protein and SOX10 IHC when diagnosing tumors with predominantly oncocytoma-like differentiation. WebOct 1, 2012 · Sox10 is a marker of neural crest origin and is expressed in melanoma and peripheral nerve sheath tumors. •. This article explores Sox10 expression in various …

Cytoplasmic sox10

Did you know?

WebJan 4, 2024 · Confocal microscopy (Fig. 4e, f) demonstrated predominantly cytoplasmic localization in most of the SOX2x3Mut-transduced NSC, whether they had initiated differentiation (white arrowheads) or not... WebApr 5, 2013 · Nuclear staining of >10% tumor cells was considered positive for SOX10 and p63; cytoplasmic staining for Smooth muscle actin, calponin, CK14, CK5/6 and Glial fibrillary acidic protein; both ...

WebSep 15, 2015 · Whereas SOX10 has a nuclear localisation in the embryonic neural crest, hEPI-NCSC showed predominantly cytoplasmic SOX10 immunoreactivity. WNT and SHH signalling are part of the network that regulates SOX10 expression ( Werner et al., 2007 ; McNeill et al., 2012 ), which explains the increased nuclear SOX10 localisation in hEPI … WebSox10 shuttles between the nucleus and the cytoplasm. Since Sox10 can be found in the nucleus as well as in the cytoplasm, we addressed the question whether Sox10 has nu- cleocytoplasmic shuttling ...

WebJan 10, 2024 · To isolate single Sox10 + /FSP1 − cells from Sox10 + /FSP1 + cells, we plated the mixed cell population at very low density (~100 cells per 100-mm dish), and … WebJun 19, 2024 · In contrast to S100, which is expressed in both the nucleus and cytoplasm, SOX10 is confined to the nucleus, enabling double staining to be performed on paraffin …

WebApr 5, 2013 · Appropriate positive and negative controls were used for each antibody. Nuclear staining of >10% tumor cells was considered positive for SOX10 and p63; cytoplasmic staining for Smooth muscle actin...

WebA weak cytoplasmic staining reaction in cells with a strong nuclear staining reaction was accepted. Participation Number of laboratories registered for SOX10, run 55 211 Number of laboratories returning slides 204 (97%) Results 204 laboratories participated in this assessment. 181 (89%) achieved a sufficient mark (optimal or good). target batch app downloadWebNov 4, 2024 · SOX10 positivity is also commonly expressed in both mixed tumors and myoepitheliomas (~80%), but is only present in a minor percentage of myoepithelial carcinomas (Fig. 3f) . Other markers of ... target bath and body gift setsWebAug 20, 2015 · Results: SOX-10 showed exclusive nuclear positivity in 100% of the uveal melanoma cases (38/38). HMB-45 showed cytoplasmic positivity in 97.3 (37/38). … target batavia pharmacy hoursWebIn accord with its function as transcription factor, Sox10 contains two nuclear localization signals and is most frequently detected in the nucleus. In this study, we report that … target bath bomb moldsWebSOX10/keratin dual-color immunohistochemistry: An effective first-line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens SOX10/keratin dual-color immunohistochemistry: An effective first-line test for the workup of epithelioid malignant neoplasms in FNA and small biopsy specimens target bath floor matsWebNuclear and cytoplasmic Expression in Normal Tissues [] This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. In the central nervous system, … target bath bomb kitWebThis granular cell tumor shows strong nuclear and cytoplasmic expression in virtually all of the tumor cells. The tumor cells surround a small peripheral nerve , which also expresses … target bath hand towels