Pttg1 and p53

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August undefined, 2024

WebObjective To analyze the expression of pituitary tumor transforming gene 1 (PTTG1) in hepatocellular carcinoma (HCC) and its clinical prognostic implication. ... p53 signaling pathway and human T-lymphotropic virus (HTLV) infection. PTTG1 and its co-expressed genes were mutated to some extent in HCC, and significantly shortened OS and DFS in ... WebApr 20, 2006 · To this end, we examined the effect of PTTG1 depletion on endogenous levels of p53 and p21. p21 is one of many genes to be induced by p53 and functions as a cyclin-dependent kinase inhibitor, which induces in cell-cycle arrest at G1 phase. 34 p53 level was not markedly affected by PTTG1 depletion, but p21 level was increased in a viral …

Clinical significance and potential regulatory mechanism of ...

WebJul 8, 2004 · PTTG upregulates expression of p53 in HEK293 and MCF-7 cells. To determine the relationship between PTTG and p53, we first determined the effect of overexpression of PTTG on p53 expression. For this purpose, we used three different cell lines. Two of these HEK293, which is a human embryonic kidney cell line, and MCF-7, which is a human … WebAug 17, 2011 · Cell lines and reagents. HCT116 is a human colon carcinoma cell line, expressing wild-type p53 and PTTG1 genes, and HCT116 p53 −/− and HCT116 PTTG1 −/− cell lines were derived using homologous recombination to knock out p53 or PTTG1 respectively , .Cells were cultured in McCoy's 5A medium containing 15% FBS. song from the 50s hey baby

PTTG1 - Wikipedia

WebDec 25, 2024 · Nnegative pituitary tumor-transforming gene 1 protein-interacting protein (PTTG1IP) immunoexpression predicted a 1.5-fold risk of breast cancer death. ... protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are rare compared with other tumor … WebOct 20, 2008 · They also observed apoptosis by PTTG1 in p53-negative MG-63 cells. The transient or stable expressions of PTTG1 in these cells were found to increase the frequency of aneuploidy. ... Puri R, Tousson A, Chen L, Kakar SS: Molecular cloning of pituitary tumor transforming gene 1 from ovarian tumors and its expression in tumors. Cancer Lett 2001 ... WebSep 23, 2002 · a, Schematic diagram of human p53 and the shorter PTTG1-interacting TP53 cDNA. The structure of p53 is shown, including the transactivation domain (TA), DNA-binding domain (DB), tetramerization ... smaller car lots in tucson

PTTG1 expression is associated with hyperproliferative …

PTTG1 attenuates drug-induced cellular senescence - PubMed

WebOct 1, 2015 · For example, PTTG1 (securin) specifically bound to p53 and interfered with DNA binding of p53, significantly reducing the transcriptional activity of p53 on p53-specific promoters . In this study, we present evidence that PTTG1, behaving as a miR-329, miR-300, miR-381 and miR-655 target gene, acts to mediate cell transformation and tumor formation. WebAug 23, 2024 · The p53 Signaling PCR array includes 24 genes involved in cell cycle regulation. Results indicate that nine of these genes were significantly altered in FLT samples. ... PTTG1 (Pituitary tumor-transforming gene 1) regulates the cell cycle by inducing cyclin D3 and repressing p21 expression . smaller calves smaller camping trailer

"WebSep 26, 2024 · pituitary tumor-transforming gene 1 protein-interacting protein, PTTG-binding factor, pituitary tumor-transforming gene protein-binding factor GeneRIFs: Gene References Into Functions protooncogene PBF is a negative regulator of p53 function in thyroid tumorigenesis, in which PBF is generally overexpressed and p53 mutations are … " - Pttg1 and p53

Pttg1 and p53

Role of the pituitary tumor transforming gene 1 in the ... - PubMed

WebJul 16, 2010 · Significantly, the PTTG1-induced senescence is p53-dependent and telomerase-independent, which is distinctively different from that of replicative senescence. The mechanism of PTTG1-induced senescence was also analyzed. Consistent with its role in regulating sister-chromatid separation, overexpression of PTTG1 inhibited the … WebJul 28, 2008 · Pituitary tumor transforming gene 1 (PTTG1), a transforming gene highly expressed in several cancers, is a mammalian securin protein regulating both G1/S and G2/M phases. ... PTTG1 inhibits p53 ...

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WebAug 18, 2024 · It should be noted that the PTTG family interacts with p53. For example, PTTG1 is thought to influence p53 activity by blocking p53 binding to DNA . Moreover, Méndez-Vidal et al. indicated that PTTG2 silencing results in increased levels of p53 protein . Suppressor p53 serves an important role in the cellular homeostasis maintenance . WebOct 6, 2015 · Notably, some of the genes found to strongly correlate with PTTG1 expression in this study, including CDK1, CCNB1, CCNB2 and BIRC5 are known to be inhibited downstream of p53 [68–70]; p53-mediated regulation of gene expression down stream of PTTG1 could be a focus of future studies. However, we found no correlation between …

WebOn the other hand, PTTG1 is a p53 target gene, and p53 inhibits NF-Y binding to the PTTG1 promoter and thus inhibits PTTG expression [226, 227]. Alternatively, p53 inhibits PTTG expression by ... WebJun 29, 2024 · Background Pituitary tumor transforming gene-1 (PTTG1) transcription factor is identified as carcinogenic and associated with tumor invasiveness, but its role in bladder cancer (BLCA) remains obscure. This research is intended to analyze the aberrant expression and clinical significance of PTTG1 in BLCA, explore the relationship between …

WebPTTG1 has been shown to interact with: DNAJA1, Ku70; P53, PTTG1IP, and; RPS10. Regulation. During Mitosis CDK1 phosphorylate PTTG1 at Ser-165. PTTG1 is down-regulated in melanoma cells in response to the cyclin-dependent kinase … Webp53 dysfunction has previously been shown to activate PPP and contribute to the Warburg effect. ... Molina-Jimenez F, Benedicto I, Murata M, et al. Expression of pituitary tumor-transforming gene 1 (PTTG1)/securin in hepatitis B virus (HBV)-associated liver diseases: evidence for an HBV X protein-mediated inhibition of PTTG1 ubiquitination and ...

WebNov 21, 2012 · Human pituitary tumor transforming gene-1 (PTTG1) is a novel oncogene. ... PTTG1 staining was one of the histological features (numerous mitoses, high Ki-67 index, and nuclear labelling of PTTG1 and P53) distinguishing aggressive–invasive PRL tumors from those behaving less aggressively ...

WebMar 12, 2007 · For example, PTTG1 may bind to p53 and inhibit p21 transactivation (Bernal et al., 2002) which facilitates Rb phosphorylation, enabling the G1/S transition. c-Myc, induced by PTTG1, may in turn ... smaller camera backpacks for travelWebFeb 24, 2024 · Pituitary tumor-transforming gene-1 (PTTG1), one type of DNA repair-related gene, has been reported to be dysregulated in several tumors and serve as a tumor promotor. Previously, the oncogenic roles of PTTG1 were also reported in lung adenocarcinoma (LUAD). However, the prognostic values of PTTG1 in LUAD and the … smaller cells are very active as they haveWebJul 28, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) has been identified as an oncogene and is overexpressed in many tumor types. However, the role of PTTG1 in glioblastoma (GBM) has not been well characterized, especially in relation to angiogenesis, migration, and invasion. ... VEGF, MMP2, MMP9, MMP14, p53, p21 and cyclin D1. Pearson … smaller camping backpacksWebPituitary tumor-transforming gene 1 protein (PTTG1) immunostaining and P53 expression. Source publication Upregulation of PTTG1 is associated with poor prognosis in prostate cancer smaller catechismWebFeb 25, 2024 · Pituitary tumor-transforming gene 1 (PTTG1) encodes a multifunctional protein that is involved in many cellular processes. However, the potential role of PTTG1 in tumor formation and its prognostic function in human pan-cancer is still unknown. ... Moreover, the UBE2C-mediated P53 ubiquitination could be a potential target in LIHC … song from sweet toothWebJun 21, 2024 · In addition, the existence of a complex network among p53 family members (p63 and p73) and their interactions with other factors that promote thyroid cancer progression has been well documented. ... The PTTG1-binding factor (PBF/PTTG1IP) regulates p53 activity in thyroid cells. Endocrinology 2014, 155, 1222–1234. [Google … song from teen titansWebThe PTTG1-Binding Factor (PBF/PTTG1IP) has an emerging repertoire of roles, especially in thyroid biology, and functions as a proto-oncogene. ... Impaired p53 function was evident in a transgenic mouse model with thyroid-specific PBF over-expression (PBF-Tg), which had significantly increased genetic instability as indicated by FISSR-PCR ... song from the batman